Publications
Magnetic Resonance Imaging Textural Changes Are More Sensitive Than Volumetric Changes in the Amygdala of Cocaine Use Disorder Patients
Nandi, S., Poojar, P., Taufique, S., Weller, R., Bachi, K., Hurd, Y. L. & Geethanath, S.
Evaluating a Multi-Pronged Initiative to Decrease Racial and Ethnic Inequities in the Identification of Maternal Substance Use: Successes, Challenges, and Lessons Learned
Besculides, M., Klepser, N. S., Agarwal, P., Merchant, R. C, Hurd, Y. L., & Habersham, L. L.
Cannabidiol Attenuates Heroin Seeking in Male Rats Associated with Normalization of Discrete Neurobiological Signatures within the Nucleus Accumbens with Subregional Specificity.
Chisholm, A., Ferland, J. N., Ellis, R. J., & Hurd ,Y. L.
Machine Learning Analysis of the Orbitofrontal Cortex Transcriptome of Human Opioid Users Identifies Shisa7 as a Translational Target Relevant for Heroin Seeking Leveraging a Male Rat Model
Ellis, R. J., Ferland, J. N., Rahman, T., Landry, J. L., Callens, J. E., Pandey, G., Lam, T., Kanyo, J., Nairn, A. C, Dracheva, S. & Hurd, Y. L.
An Update on the Behavioral and Neurobiological Effects of Cannabis Use in Adolescents: A Translational Perspective
Hurd, Y. L.
Substance Use and Use Disorders During Pregnancy and the Postpartum Period
Habersham, L. L., Townsel, C., Terplan, M., & Hurd, Y. L.
Cannabidiol Abrogates Cue-Induced Anxiety Associated with Normalization of Mitochondria-Specific Transcripts and Linoleic Acid in the Nucleus Accumbens Shell
Ferland, J. N., Chisholm, A., Abdalla, J., Cinar, R., Johnson, C., Bradshaw, H. B., & Hurd, Y. L.
The Developmental Trajectory to Cannabis Use Disorder
Hinckley, J. D., Ferland, J. N., & Hurd, Y. L.
An Institutional Intervention on Toxicology Testing Reduces Inequities During the Birthing Hospitalization
Habersham, L. L., Bianco, A. T., Kudrich, C. J., Woolfolk, C. L., Stern, T. A., Stone, J. L., & Hurd, Y. L.
Cannabis Use and the Developing Brain: Highs and Lows
Hurd, Y. L., Ferland, J. N., Nomura, Y., Hulvershorn, L. A., Gray, K. M., & Thurstone, C.
Profiling Neuronal Methylome and Hydroxymethylome of Opioid Use Disorder in the Human Orbitofrontal Cortex
Rompala, G., Nagamatsu, S. T., Martínez-Magaña, J. J., Nuñez-Ríos, D. L., Wang, J., Girgenti, M. J., Krystal, J. H., Gelernter, J., Traumatic Stress Brain Research Group, Hurd, Y. L., & Montalvo-Ortiz, J. L.
Prenatal Exposure to a Natural Disaster and Early Development of Psychiatric Disorders During the Preschool Years: Stress in Pregnancy Study
Nomura, Y., Newcorn, J. H., Ginalis, C., Heitz, C., Zaki, J., Khan, F., Nasrin, M., Sie, K., DeIngeniis, D., & Hurd, Y. L.
Dose Mediates the Protracted Effects of Adolescent Thc Exposure on Reward and Stress Reactivity in Males Relevant to Perturbation of the Basolateral Amygdala Transcriptome
Ferland, J. N., Ellis, R. J., Rompala, G., Landry, J. A., Callens, J. E., Ly, A., Frier, M. D., Uzamere, T. O., & Hurd, Y. L.
Transcriptional Signatures of Heroin Intake and Seeking Throughout the Brain Reward Circuit
Browne, C. J., Futamura, R., Minier-Toribio, A., Hicks, E.M., Ramakrishnan, A., Martínez-Rivera, F., Estill, M., Godino, A., Parise, E. M., Torres-Berrío, A., Cunningham, A. M., Hamilton, P. J., Walker, D. M., Huckins, L. M., Hurd, Y. L., Shen, L., & Nestler, E. J.
Long-term Outcomes of Adolescent Thc Exposure on Translational Cognitive Measures in Adulthood in an Animal Models and Computational Assessment of Human Data
Ferland, J. N., Ellis, R. J., Betts, G., Silveira, M. M., de Firmino, J. B., Winstanley, C. A., & Hurd, Y. L.
A Randomized, Triple-blind, Comparator-controlled Parallel Study Investigating the Pharmacokinetics of Cannabidiol and Tetrahydrocannabinol in a Novel Delivery System, Solutech, in Association with Cannabis Use History
Berl, V., Hurd, Y. L., Lipshutz, B. H., Roggen, M., Mathur, E. J., & Evans, M.
Stress in Pregnancy: Clinical and Adaptive Behavior of Offspring Following Superstorm Sandy
Nomura, Y., Zhang, W., & Hurd, Y. L.
Adjunctive Management of Opioid Withdrawal with the Non-opioid Medication Cannabidiol
Kudrich, C., Hurd, Y. L., Salsitz, E., & Wang, A. L.
Prenatal Δ9-tetrahydrocannabinol Exposure in Males Leads to Motivational Disturbances Related to Striatal Epigenetic Dysregulation
Ellis, R. J., Bara, A., Vargas, C. A., Frick, A. L., Loh, E., Landry, J., Uzamere, T. O., Callens, J. E., Martin, Q., Rajarajan, P., Brennand, K., Ramakrishnan, A., Shen, L., Szutorisz, H., & Hurd, Y. L.
Overcoming Addiction Stigma: Epigenetic Contributions to Substance Use Disorders and Opportunities for Intervention
Szutorisz, H., & Hurd, Y.L.
Respiratory Failure in Confirmed Synthetic Cannabinoid Overdose
Manini, A. F., Krotulski, A. J., Schimmel, J., Allen, L., Hurd, Y. L., Richardson, L. D., Vidal, K., & Logan, B. K.
Data Mining-based Clinical Profiles of Substance Use-related Emergency Department Utilizers
Monti, K., Bachi, K., Gray, M., Mahajan, V., Sweeney, G., Oprescu, A. M., Munjal, K. G., Hurd, Y. L., & Lim, S.
Responding to the Opioid Crisis in North America and Beyond: Recommendations of the Stanford-lancet Commission
Humphreys, K., Shover, C. L., Andrews, C. M., Bohnert, A. S. B., Brandeau, M. L., Caulkins, J. P., Chen, J. H., Cuéllar, M. F., Hurd, Y. L., Juurlink, D. N., Koh, H. K., Krebs, E. E., Lembke, A., Mackey, S. C., Larrimore Ouellette, L., Suffoletto, B., & Timko, C.
Neural Underpinnings of Social Stress in Substance Use Disorders
Sahani, V., Hurd, Y. L., & Bachi, K.
Dysregulated Expression of the Alternatively Spliced Variant Mrnas of the Mu Opioid Receptor Gene, Oprm1, in the Medial Prefrontal Cortex of Male Human Heroin Abusers and Heroin Self-administering Male Rats
Brown, T. G., Xu, J., Hurd, Y. L., & Pan, Y. X.
Maternal Cannabis Use Is Associated with Suppression of Immune Gene Networks in Placenta and Increased Anxiety Phenotypes in Offspring
Rompala, G., Nomura, Y., & Hurd, Y. L.
Natural Disaster Stress During Pregnancy Is Linked to Reprogramming of the Placenta Transcriptome in Relation to Anxiety and Stress Hormones in Young Offspring
Nomura, Y., Rompala, G., Pritchett, L., Aushev, V., Chen, J., & Hurd, Y. L.
Cannabis and Synaptic Reprogramming of the Developing Brain
Bara, A., Ferland, J. N., Rompala, G., Szutorisz, H., & Hurd, Y. L.
Common Schizophrenia Risk Variants Are Enriched in Open Chromatin Regions of Human Glutamatergic Neurons
Hauberg, M. E., Creus-Muncunill, J., Bendl, J., Kozlenkov, A., Zeng, B., Corwin, C., Chowdhury, S., Kranz, H., Hurd, Y. L., Wegner, M., Børglum, A. D., Dracheva, S., Ehrlich, M. E., Fullard, J. F., & Roussos, P.
Reflections on the Past Two Decades of Neuroscience
Bassett, D. S., Cullen, K. E., Eickhoff, S. B., Farah, M. J., Goda, Y., Haggard, P., Hu, H., Hurd, Y. L., Josselyn, S. A., Khakh, B. S., Knoblich, J. A., Poirazi, P., Poldrack, R. A., Prinz, M., Roelfsema, P. R., Spires-Jones, T. L., Sur, M., & Ueda, H. R.
Chromatin Accessibility Mapping of the Human Striatum Identifies Tyrosine Kinase Fyn as a Promising Therapeutic Target for Heroin Use Disorder
Egervari, G., Akpoyibo, D., Rahman, T., Fullard, J. F., Callens, J. E., Landry, J. A., Ly, A., Zhou, X., Warren, N., Hauberg, M .E., Hoffman, G., Ellis, R., Ferland, J. M., Miller, M. L., Keller, E., Zhang, B., Roussos, P., & Hurd. Y. L.
Cannabis and the Developing Brain Challenge Risk Perception
Hurd, Y. L.
Addressing Racism and Disparities in the Biomedical Sciences
Clark, U. S., & Hurd, Y. L.
Deconstructing the Neurobiology of Cannabis Use Disorder
Ferland, J. N., & Hurd, Y. L.
Cannabidiol for the Reduction of Cue-induced Craving and Anxiety in Drug-abstinent Individuals with Heroin Use Disorder: A Double-blind Randomized Placebo-controlled Trial
Hurd, Y. L., Spriggs, S., Alishayev, J., Winkel, G., Gurgov, K., Kudrich, C., Oprescu, A. M. and Salsitz, E.
Microbiota of Newborn Meconium Is Associated with Maternal Anxiety Experienced During Pregnancy.
Hurd, Y. L., Spriggs, S., Alishayev, J., Winkel, G., Gurgov, K., Kudrich, C., Oprescu, A. M., & Salsitz, E.
Molecular Windows into the Human Brain for Psychiatric Disorders
Egervari, G., Kozlenkov, A., Dracheva, S., & Hurd, Y. L.
Adolescent Exposure to Δ9-tetrahydrocannabinol Alters the Transcriptional Trajectory and Dendritic Architecture of Prefrontal Pyramidal Neurons
Miller, M. L., Chadwick, B., Dickstein, D. L., Purushothaman, I., Egervari, G., Rahman, T., Tessereau, C., Hof, P. R., Roussos, P., Shen, L., Baxter, M. G., & Hurd, Y. L.
Molecular Genetics and New Medication Strategies for Opioid Addiction
Hurd, Y. L., & O'Brien, C. P.
Can a Framework Be Established for the Safe Use of Ketamine?
Freedman, R., Brown, A.S., Cannon, T. D., Druss, B. G., Earls, F.J., Escobar, J., Hurd, Y. L., Lewis, D.A., López-Jaramillo, C., Luby, J., Mayberg, H. S., Moffitt, T. E., Oquendo, M., Perlis, R. H., Pine, D. S., Rush, A. J., Tamminga, C. A., Tohen, M., Vieta, E., Wisner, K. L., & Xin, Y.
Thc Exposure of Human Ipsc Neurons Impacts Genes Associated with Neuropsychiatric Disorders
Guennewig, B., Bitar, M., Obiorah, I., Hanks, J., O'Brien, E. A., Kaczorowski, D. C., Hurd, Y. L., Roussos, P., Brennand, K. J., & Barry, G.
Cannabidiol, an Adjunct Player in the Antipsychosis Arsenal
Bassir Nia, A. and Hurd, Y.L.
Shaping Vulnerability to Addiction - the Contribution of Behavior, Neural Circuits and Molecular Mechanisms
Egervari, G., Ciccocioppo, R., Jentsch, J. D., & Hurd, Y. L.
Granulocyte-colony Stimulating Factor Controls Neural and Behavioral Plasticity in Response to Cocaine.
Calipari, E. S., Godino, A., Peck, E. G., Salery, M., Mervosh, N. L., Landry, J. A., Russo, S. J., Hurd, Y. L., Nestler, E. J., & Kiraly, D. D.
Acute Engagement of Gq-mediated Signaling in the Bed Nucleus of the Stria Terminalis Induces Anxiety-like Behavior
Mazzone, C. M., Pati, D., Michaelides, M., DiBerto, J., Fox, J. H., Tipton, G., Anderson, C., Duffy, K., McKlveen, J. M., Hardaway, J. A., Magness, S. T., Falls, W. A., Hammack, S. E., McElligott, Z. A., Hurd, Y. L., & Kash, T. L.
Cocaine-induced Chromatin Modifications Associate with Increased Expression and Three-dimensional Looping of Auts2
Engmann, O., Labonté, B., Mitchell, A., Bashtrykov, P., Calipari, E. S., Rosenbluh, C., Loh, Y. E., Walker, D. M., Burek, D., Hamilton, P. J., Issler, O., Neve, R. L., Turecki, G., Hurd, Y. L., Chess, A., Shen, L., Mansuy, I., Jeltsch, A., Akbarian, S., & Nestler, E. J.
The Endocannabinoid System as a Target for Addiction Treatment: Trials and Tribulations
Sloan, M. E., Gowin, J. L., Ramchandani, V. A., Hurd, Y. L., & Le Foll, B.
Perioperative Patient Beliefs Regarding Potential Effectiveness of Marijuana (cannabinoids) for Treatment of Pain: A Prospective Population Survey
Khelemsky, Y., Goldberg, A. T., Hurd, Y. L., Winkel, G., Ninh, A., Qian, L., Oprescu, A., Ciccone, J., & Katz, D. J.
Dna Methylation Profiling of Human Prefrontal Cortex Neurons in Heroin Users Shows Significant Difference Between Genomic Contexts of Hyper- and Hypomethylation and a Younger Epigenetic Age
Kozlenkov, A., Jaffe, A. E., Timashpolsky, A., Apontes, P., Rudchenko, S., Barbu, M., Byne, W., Hurd, Y. L., Horvath, S., & Dracheva, S.
High Times for Cannabis: Epigenetic Imprint and Its Legacy on Brain and Behavior
Szutorisz, H., & Hurd, Y. L.
Testing the Gateway Hypothesis
Miller, M. L., & Hurd, Y. L.
Striatal H3k27 Acetylation Linked to Glutamatergic Gene Dysregulation in Human Heroin Abusers Holds Promise as Therapeutic Target
Egervari, G., Landry, J., Callens, J., Fullard, J. F., Roussos, P., Keller, E., & Hurd, Y. L.
Cannabidiol: Swinging the Marijuana Pendulum from “weed” to Medication to Treat the Opioid Epidemic
Hurd, Y. L.
Ventral Striatal Regulation of Crem Mediates Impulsive Action and Drug Addiction Vulnerability
Miller, M.L., Ren, Y. Szutorisz, H., Warren, N.A., Tessereau, C., Egervári, G., Mlodnicka, A., Kapoor, M., Chaarani, B., Morris, C.V., Schumann, G., Garavan, H., Goate, A.M., Bannon, M.J., IMAGEN Consortium, Halperin, J.M., & Hurd, Y. L.
Sex and Age Specific Effects of Delta-9-tetrahydrocannabinol During the Periadolescent Period in the Rat: the Unique Susceptibility of the Prepubescent Animal
Silva, L., Black, R., Michaelides, M., Hurd, Y. L., & Dow-Edwards, D.
Psychiatric Comorbidity Associated with Synthetic Cannabinoid Use Compared to Cannabis
Bassir Nia, A., Medrano, B., Perkel, C., Galynker, I., & Hurd, Y. L.
Cross-generational Thc Exposure Alters the Developmental Sensitivity of Ventral and Dorsal Striatal Gene Expression in Male and Female Offspring
Szutorisz, H., Egervári, G., Sperry, J., Carter, J. M., & Hurd, Y. L.
Genome-wide Dna Methylation Profiling Reveals Epigenetic Changes in the Rat Nucleu
Watson, C. T., Szutorisz, H., Garg, P., Martin, Q., Landry, J. A., Sharp, A. J., & Hurd, Y. L.
Epigenetic Effects of Cannabis Exposure
Szutorisz, H., & Hurd, Y. L.
Heroin Abuse Exaggerates Age-related Deposition of Hyperphosphorylated Tau and P62-positive Inclusions
Kovacs, G. G., Horvath, M. C., Majtenyi, K., Lutz, M. I., Hurd, Y. L., & Keller, E.
Endocannabinoid Signalling in Reward and Addiction
Parsons, L. H., & Hurd, Y. L.
Early Phase in the Development of Cannabidiol as a Treatment for Addiction: Opioid Relapse Takes Initial Center Stage
Hurd, Y. L., Yoon, M., Manini, A. F., Hernandez, S., Olmedo, R., Ostman, M., & Jutras-Aswad, D.
Safety and Pharmacokinetics of Oral Cannabidiol When Administered Concomitantly with Intravenous Fentanyl in Humans
Manini, A. F., Yiannoulos, G., Bergamaschi, M. M., Hernandez, S., Olmedo, R., Barnes, A. J., Winkel, G., Sinha, R., Jutras-Aswad, D., Huestis, M. A., & Hurd, Y. L.
Neuronal Substrates and Functional Consequences of Prenatal Cannabis Exposure
Calvigioni, D., Hurd, Y. L., Harkany, T., & Keimpema, E.
Endocannabinoids Modulate Cortical Development by Configuring Slit2/robo1 Signaling
Alpár, A., Tortoriello, G., Calvigioni, D., Niphakis, M. J., Milenkovic, I., Bakker, J., Cameron, G. A., Hanics, J., Morris, C. V., Fuzik, J., Kovacs, G. G., Cravatt, B. F., Parnavelas, J. G., Andrews, W. D., Hurd, Y. L., Keimpema, E., & Harkany, T.
Parental Thc Exposure Leads to Compulsive Heroin-seeking and Altered Striatal Synaptic Plasticity in the Subsequent Generation
Szutorisz, H., DiNieri, J. A., Sweet, E., Egervari, G., Michaelides, M., Carter, J. M., Ren, Y., Miller, M. L., Blitzer, R. D., & Hurd, Y. L.
Miswiring the Brain: Δ9-tetrahydrocannabinol Disrupts Cortical Development by Inducing an Scg10/stathmin-2 Degradation Pathway
Tortoriello, G., Morris, C. V., Alpar, A., Fuzik, J., Shirran, S. L., Calvigioni, D., Keimpema, E., Botting, C. H., Reinecke, K., Herdegen, T., Courtney, M., Hurd, Y. L., & Harkany, T.
Trajectory of Adolescent Cannabis Use on Addiction Vulnerability
Hurd, Y. L., Michaelides, M., Miller, M. L., & Jutras-Aswad, D.
In Vivo Cell-specific Mesocorticolimbic Whole-brain Circuit Dissection in Freely-moving Animals
Michaelides, M., Anderson, S. A., Ananth, M., Smirnov, D., Thanos, P. K., Neumaier, J. F., Wang, G. J., Volkow, N. D., & Hurd, Y. L.
Cannabis Use During Adolescent Development: Susceptibility to Psychiatric Illness
Chadwick, B., Miller, M. L., & Hurd, Y. L.
Elk1 Transcription Factor Linked to Dysregulated Striatal Mu Opioid Receptor Signaling Network and Oprm1 Polymorphism in Human Heroin Abusers
Daws, S. E., Whittard, J. D., Jacobs, M. M., Ren, Y., Mazloom, A. R., Caputti, F., Horvath, M., Keller, E., Ma’ayan, E., Pan, Y-X., Chiang, L. W., & Hurd Y. L. (2013)
Maternal Cannabis Use Alters Ventral Striatal Dopamine D2 Gene Regulation in the Offspring
DiNieri, J. A., Wang, X., Szutorisz, H., Spano, S. M., Kaur, J., Casaccia, P., Dow-Edwards, D., & Hurd Y. L.
Dnmt3a Regulates Emotional Behavior and Spine Plasticity in the Nucleus Accumbens
Laplant, Q., Vialou, V., Covington, H .E., Dumitriu, D., Feng, J., Warren, B. L., Maze, I., Dietz, D. M., Watts, E. L., Iñiguez, S. D., Koo, J. W., Mouzon, E., Renthal, W., Hollis, F., Wang, H., Noonan, M. A., Ren, Y., Eisch, A.J., Bolaños, C. A., Kabbaj, M., Xiao, G., Neve, R. L., Hurd, Y. L., Oosting, R. S., Fan, G., Morrison, J. H., & Nestler, E. J.
Essential Role of the Histone Methyltransferase G9a in Cocaine-induced Plasticity
Maze, I., Covington, H. E., 3rd, Dietz, D. M., LaPlant, Q., Renthal, W., Russo, S. J., Mechanic, M., Mouzon, E., Neve, R. L., Haggarty, S. J., Ren, Y., Sampath, S. C., Hurd, Y. L., Greengard, P., Tarakhovsky, A., Schaefer, A., & Nestler, E. J.
Cannabidiol, a Nonpsychotropic Component of Cannabis, Inhibits Cue-induced Heroin-seeking and Normalizes Discrete Mesolimbic Neuronal Disturbances
Ren, Y., Whittard, J., Higuera-Matas, A., Morris, C. V., & Hurd, Y. L.
Opioid Neuropeptide Genotypes in Relation to Heroin Abuse: Dopamine Tone Contributes to Reversed Mesolimbic Proenkephalin Expression
Nikoshkov, A., Drakenberg, K., Wang, X., Horváth, M. C., Keller, E., & Hurd, Y. L.
Adolescent Cannabis Exposure Alters Opiate Intake and Opioid Limbic Neuronal Populations in Adult Rats
Ellgren, M., Spano, S. M., & Hurd, Y. L.
Μ Opioid Receptor A118g Polymorphism in Association with Striatal Opioid Neuropeptide Gene Expression in Heroin Abusers
Drakenberg, K., Nikoshkov, A., Horváth, M. C., Fagergren, P., Gharibyan, A., Saarelainen, K., Rahman, S., Nylander, I., Bakalkin, G., Rajs, J., Keller, E., & Hurd, Y. L.
In Utero Marijuana Exposure Associated with Abnormal Amygdala Dopamine D2 Gene Expression in the Human Fetus
Wang, X., Dow-Edwards, D., Andersen, V., Minkoff, H., & Hurd, Y.L.
Anatomical Distribution of Neurokinin 1 Receptor and Relative Abundance of the Short and Long Isoforms in the Human Brain
Caberlotto, L., Hurd, Y. L., Murdock, P., Wahlin, J. P., Melotto, S., Corsi, M., & Carletti, R.
Subjects with Major Depression or Bipolar Disorder Show Reduction of Prodynorphin Mrna Expression in Discrete Nuclei of the Amygdaloid Complex
Hurd, Y. L.
D1 and D2 Dopamine Receptor Mrna Expression in Whole Hemisphere Sections of the Human Brain
Hurd, Y. L., Suzuki, M., & Sedvall, G. C.
Prodynorphin Mrna Expression Is Increased in the Patch Vs Matrix Compartment of the Caudate Nucleus in Suicide Subjects
Hurd, Y. L., Herman, M. M., Hyde, T .M., Bigelow, L. B., Weinberger, D. R., & Kleinman, J. M.
Molecular Alterations in the Neostriatum of Human Cocaine Addicts
Hurd, Y. L., & Herkenham, M.
Neurochemical Correlates of Cocaine and Ethanol Self-administration
Weiss, F., Hurd, Y. L., Ungerstedt, U., Markou, A., Plotsky, P. M., & Koob, G. F.
Cocaine Self-administration Differentially Alters Mrna Expression of Striatal Neuropeptides
Hurd, Y. L., Brown, E. E., Finlay, J. M., Fibiger, H. C., & Gerfen, C. R.
Cocaine Reinforcement and Extracellular Dopamine Overflow: an in Vivo Microdialysis Study
Hurd, Y. L., Weiss, F., Koob, G. F., And, N. E., & Ungerstedt, U.
Cocaine: an in Vivo Microdialysis Evaluation of Its Acute Action on Dopamine Transmission in Rat Striatum
Hurd, Y. L., & Ungerstedt, U.
